ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

Base Information

Chemical Name:ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate
CAS No.:1363621-27-5
Molecular Formula:C₂₆H₁₉Cl₃N₂O₅
Molecular Weight:545.806
Hs Code.:

Synonyms:ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

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Chemical Property of ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

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Technology Process of ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

There total 9 articles about ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.04%

: 1363621-26-4
ethyl 5-amino-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

: 122-01-0
4-chloro-benzoyl chloride

: 1363621-27-5
ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2012.01.007

Reference yield:

: 149288-99-3
ethyl 4-(2,6-dichlorobenzyloxy)benzoate

: 1363621-27-5
ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 2 h / Reflux

1.2: pH 4 - 5

2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 5 h / Reflux

3.1: 1-methyl-pyrrolidin-2-one / 20 - 25 °C

4.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2012.01.007

Reference yield:

: 149289-09-8
4-(2,6-dichlorobenzyloxy)benzoic acid

: 1363621-27-5
ethyl 5-(4-chlorobenzamido)-2-(4-(2,6-dichlorobenzyloxy)phenyl)oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 5 h / Reflux

2: 1-methyl-pyrrolidin-2-one / 20 - 25 °C

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/j.ejmech.2012.01.007