C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-)

Base Information

• Chemical Name: C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-)
• CAS No.: 1353554-57-0
• Molecular Formula: C₂₆H₂₅FNO₄*I
• Molecular Weight: 561.392
• Mol file: 1353554-57-0.mol

Synonyms:C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-)

Chemical Property of C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-)

There total 8 articles about C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

C25H22FNO4 (1353554-56-9) + methyl iodide (74-88-4) → C26H25FNO4(1+)*I(1-) (1353554-57-0)

Guidance literature:

at 60 ℃; for 2h; Inert atmosphere;

Reference yield:

3,4-dimethoxyaniline (6315-89-5) → C26H25FNO4(1+)*I(1-) (1353554-57-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 12 h / Inert atmosphere; Reflux

1.2: pH 9

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 20 - 60 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / -78 - 0 °C / Inert atmosphere

5.1: potassium carbonate / palladium diacetate; XPhos / 1,4-dioxane; water / 3 h / 95 °C / Inert atmosphere

6.1: 2 h / 60 °C / Inert atmosphere

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; XPhos; In 1,4-dioxane; ethanol; dichloromethane; water; 2.1: Suzuki Coupling / 5.1: Suzuki Coupling;

Reference yield:

3-bromo-6,7-dimethoxyquinoline (850352-73-7) → C26H25FNO4(1+)*I(1-) (1353554-57-0)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

2: hydrogen; acetic acid / palladium 10% on activated carbon / 20 - 60 °C / 760.05 Torr

3: triethylamine / dichloromethane / -78 - 0 °C / Inert atmosphere

4: potassium carbonate / palladium diacetate; XPhos / 1,4-dioxane; water / 3 h / 95 °C / Inert atmosphere

5: 2 h / 60 °C / Inert atmosphere

With hydrogen; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; XPhos; In 1,4-dioxane; dichloromethane; water; 1: Suzuki Coupling / 4: Suzuki Coupling;

upstream raw materials:

3,4-dimethoxyaniline

C₂₅H₂₂FNO₄

methyl iodide

3-bromo-6,7-dimethoxyquinoline

Refernces