2-Chloro-3,5-difluoroaniline

Base Information

• Chemical Name: 2-Chloro-3,5-difluoroaniline
• CAS No.: 36556-60-2
• Molecular Formula: C6H4ClF2N
• Molecular Weight: 163.554
• Hs Code.: 2921420090
• DSSTox Substance ID: DTXSID80371402
• Wikidata: Q82158722
• Mol file: 36556-60-2.mol

Synonyms:2-chloro-3,5-difluoroaniline;36556-60-2;Benzenamine, 2-chloro-3,5-difluoro-;SCHEMBL1637641;2-chloro-3,5-difluoro-aniline;DTXSID80371402;XDHOQZCRADUDRI-UHFFFAOYSA-N;MFCD00134427;2-Chloro-3,5-difluoroaniline, 97%;AKOS006229397;AC-9653;AM61932;SB76137;DS-12699;CS-0099371;FT-0611712;A823297;J-508633

Chemical Property of 2-Chloro-3,5-difluoroaniline

Chemical Property:

• Melting Point: 26-28 °C
• Refractive Index: 1.53
• Boiling Point: 208.315 °C at 760 mmHg
• PKA: 0.62±0.10(Predicted)
• Flash Point: 92.222 °C
• PSA: 26.02000
• Density: 1.459 g/cm³
• LogP: 2.78160
• Storage Temp.: Room temperature.
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 163.0000331
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

95% ^*data from raw suppliers

2-Chloro-3,5-difluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: R20/21/22;R36/37/38:
• Safety Statements: R23;R26;R45;R36/37/39:

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1N)Cl)F)F

Technology Process of 2-Chloro-3,5-difluoroaniline

There total 3 articles about 2-Chloro-3,5-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-chloro-3,5-difluoroaniline (36556-60-2)

Guidance literature:

Reference yield: 88.7%

4-amino-5-chloro-2,6-difluoroisophthalic acid diamide → 2-chloro-3,5-difluoroaniline (36556-60-2)

Guidance literature:

With sulfuric acid; In water; toluene;

Reference yield:

2-chloro-1,3,5-trifluorobenzene (2106-40-3) → 2-chloro-3,5-difluoroaniline (36556-60-2)

Guidance literature:

In methanol;

upstream raw materials:

2-chloro-1,3,5-trifluorobenzene

Downstream raw materials:

C₆H₅ClF₂N₂