2106-40-3

Basic information

• Product Name: 2,4,6-Trifluorochlorobenzene
• Synonyms: 1-CHLORO-2,4,6-TRIFLUOROBENZENE;2,4,6-TRIFLUOROCHLOROBENZENE;2-chloro-1,3,5-trifluoro-benzene;C146
• CAS NO: 2106-40-3
• Molecular Formula: C₆H₂ClF₃
• Molecular Weight: 166.53
• Mol File: 2106-40-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: -3--2 °C
• Boiling Point: 124 °C(lit.)
• Flash Point: 106 °F
• Appearance: /
• Density: 1.463 g/mL at 25 °C(lit.)
• Vapor Pressure: 14.2mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2,4,6-Trifluorochlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Trifluorochlorobenzene(2106-40-3)
• EPA Substance Registry System: 2,4,6-Trifluorochlorobenzene(2106-40-3)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 2106-40-3(Hazardous Substances Data)

Usage

General Description

2,4,6-Trifluorochlorobenzene is a chemical compound consisting of a benzene ring with three fluorine atoms and one chlorine atom attached. It is a colorless liquid with a sweet, aromatic odor and is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic chemicals. It is also used as a solvent in various industries. 2,4,6-Trifluorochlorobenzene is considered to have low toxicity, but prolonged exposure may cause irritation to the skin, eyes, and respiratory system. It is important to handle this chemical with care and follow proper safety protocols when working with it.

InChI:InChI=1/C6H2ClF3/c7-6-4(9)1-3(8)2-5(6)10/h1-2H

Upstream product

• 372-38-3 1,3,5-trifluorobenzene 
• 319-88-0 1,3,5-trichlorotrifluorobenzene 
• 118-74-1 hexachlorobenzene 
• 27074-08-4 5-chloro-2,4,6-trifluoroisophthalic acid 
• 399-36-0 N-(2,4-difluoro-phenyl)-acetamide 
• 372-39-4 3,5-difluoroaniline 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 

Downstream Products

• 372-38-3 1,3,5-trifluorobenzene 
• 36556-60-2 2-chloro-3,5-difluoroaniline 
• 325143-04-2 4,4,5,5-tetramethyl-2-(2,4,6-trifluorophenyl)-1,3,2-dioxaborolane 

Relevant articles and documents

LA FLUORATION PAR KF DE PERHALOGENES ORGANIQUES AROMATIQUES EN PRESENCE DE FAIBLES QUANTITES DE SULFOLANE OU D'EAU. SPECTRES DE MASSES DES MELANGES OBTENUS EN SERIE BENZENIQUE

The fluorinations of perhalogenated aromatic compounds with KF are carried out in sealed tubes in presence of inert gas.The addition of small quantities of aprotic solvent promotes the fluorination of pentachloropyridine above 180 deg C; these fluorinatio

Interaction of polyfluorinated 2-chloroquinolines with ammonia

We have studied the interaction of polyfluorinated (in the benzene moiety) 2-chloroquinolines with liquid and aqueous ammonia as an approach to the synthesis of halogen-containing aminoquinolines. 5,7-Difluoro-, 5,6,8-trifluoro-, and 5,7,8-trifluoro-2-chloroquinolines mostly form products of substitution of the Cl atom, whereas 5,7-difluoro-2,6-dichloroquinoline, 5,6,7,8-tetrafluoro-, and 6,7-difluoro-2-chloroquinolines yield products of substitution of an F atom at various positions. The replacement of liquid ammonia with aqueous causes an increase in the proportion of the products of aminodechlorination relative to the products of aminodefluorination. For 2-chloro-6,8-difluoroquinoline this replacement leads to 2-amino-6,8-difluoroquinoline as the main product instead of the 8-amino-derivative. Activation energy values estimated by DFT calculations for the reactions in question agree with the reaction regioselectivity observed experimentally.

Dechlorination of polychlorofluorobenzenes by the action of the reducing system NiCl2-2,2′-bipyridyl-(or 1,10-phenanthroline)-Zn-DMF-H2o

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