4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

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Chemical Name:4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride
CAS No.:1443992-73-1
Molecular Formula:C₃₁H₃₅NO₅S*ClH
Molecular Weight:570.15
Hs Code.:

Synonyms:4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

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Chemical Property of 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

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Technology Process of 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

There total 11 articles about 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443993-01-8
(3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine

: 20277-69-4
sodium methansulfinate

: 1443992-73-1
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

Guidance literature:: (3R)-1-((2S)-1-(4-(3-(3-bromophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-yl)phenoxy)propan-2-yl)-3-methylpyrrolidine; sodium methansulfinate; With copper(l) iodide; rac-Pro-OH; sodium hydroxide; In dimethyl sulfoxide; at 95 ℃;

With acetic acid; In water; at 20 ℃; for 3h;

With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield:

: (+)-(R)-2-methylbutane-1,4-diyl dimethanesulfonate

: 1443992-73-1
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 24 h / 20 °C

2.1: copper(l) iodide; potassium carbonate / 125 °C / Inert atmosphere

3.1: copper(l) iodide; rac-Pro-OH; sodium hydroxide / dimethyl sulfoxide / 95 °C

3.2: 3 h / 20 °C

With copper(l) iodide; potassium carbonate; rac-Pro-OH; sodium hydroxide; In dimethyl sulfoxide;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1443992-73-1
4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: polyphosphoric acid / 50 - 75 °C

2.1: boron tribromide / dichloromethane / 0.5 h / 0 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C

4.1: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 4.5 h / Dean-Stark; Reflux

5.1: tetrahydrofuran / 2.75 h / 0 - 20 °C

6.1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / 20 °C

7.1: copper(l) iodide; potassium carbonate / 125 °C / Inert atmosphere

8.1: copper(l) iodide; rac-Pro-OH; sodium hydroxide / dimethyl sulfoxide / 95 °C

8.2: 3 h / 20 °C

With piperidine; copper(l) iodide; pyridinium p-toluenesulfonate; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; rac-Pro-OH; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;