2-CHLORO-3-NITROPYRIDINE

Base Information

• Chemical Name: 2-CHLORO-3-NITROPYRIDINE
• CAS No.: 34515-82-7
• Molecular Formula: C₅H₃ClN₂O₂
• Molecular Weight: 158.544
• Mol file: 34515-82-7.mol

Synonyms:2-Chloro-3-nitropyridine;

Chemical Property of 2-CHLORO-3-NITROPYRIDINE

Chemical Property:

• Melting Point: 100-103 °C(lit. )
• Refractive Index: 1.454-1.456
• Boiling Point: 260.3 °C at 760 mmHg
• Flash Point: 111.2 °C
• PSA: 58.71000
• Density: 1.489 g/cm³
• LogP: 2.16640

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3-nitro-pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-3-NITROPYRIDINE

There total 1 articles about 2-CHLORO-3-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitropyridine N-oxide (2403-01-2) → 2-chloro-5-nitropyridine (4548-45-2) + 2-Chloro-3-nitropyridine (5470-18-8,34515-82-7)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 2h; Yield given. Yields of byproduct given;

Reference yield: 93.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-3-nitropyridin-2-amine (14251-85-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; Inert atmosphere; Autoclave;

DOI:10.1016/j.bmcl.2018.09.021

Reference yield: 91.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + 1-((3-chloro-4-methoxyphenyl)sulfonyl)piperidin-4-amine → N-(1-((3-chloro-4-methoxyphenyl)sulfonyl)piperidin-4-yl)-3-nitropyridin-2-amine

Guidance literature:

With triethylamine; In dimethylsulfoxide-d6; at 150 ℃; for 4h;

upstream raw materials:

3-nitropyridine N-oxide

Downstream raw materials:

3-nitropyridine-2-phenyl ether

3-nitro-2-(2-nitro-phenoxy)-pyridine

2-(4-nitrophenoxy)-3-nitropyridine

2-(methylphenylamino)-3-nitropyridine

Refernces