Technology Process of 3-oxo-12α-benzoyloxy-7α-hydroxy-24-methoxycholane
There total 7 articles about 3-oxo-12α-benzoyloxy-7α-hydroxy-24-methoxycholane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride / water / 3 h
2.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
3.1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C / Inert atmosphere
3.2: 4 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere
4.2: 6 h / 20 - 70 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 - 50 °C
6.1: silver carbonate / toluene / 4 h / Reflux
7.1: pyridine / dichloromethane / 24 h / 20 °C
With
pyridine; 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; silver carbonate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C / Inert atmosphere
1.2: 4 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere
2.2: 6 h / 20 - 70 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 - 50 °C
4.1: silver carbonate / toluene / 4 h / Reflux
5.1: pyridine / dichloromethane / 24 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; silver carbonate;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene; mineral oil;