(1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester

Base Information

• Chemical Name: (1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester
• CAS No.: 227783-07-5
• Molecular Formula: C₉H₁₄O₄
• Molecular Weight: 186.208
• Mol file: 227783-07-5.mol

Synonyms:1,3-Cyclohexanedicarboxylicacid, monomethyl ester, (1R,3S)- (9CI)

Chemical Property of (1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester

Chemical Property:

• Vapor Pressure: 0.000219mmHg at 25°C
• Boiling Point: 303.1°C at 760 mmHg
• Flash Point: 118.3°C
• PSA: 63.60000
• Density: 1.191g/cm³
• LogP: 1.05040

Purity/Quality:

97% ^*data from raw suppliers

(1R,3S)-1,3-Cyclohexanedicarboxylic acid monomethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester

There total 10 articles about (1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 3-oxabicyclo<3.3.1>nonane-2,4-dione (4355-31-1) → (1R,3S)-3-(methoxycarbonyl)cyclohexanecarboxylic acid (227783-07-5)

Guidance literature:

With 1-((1R,2R)-2-(dimethylamino)cyclohexyl)-3-phenylthiourea; In diethyl ether; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.04.121

Reference yield: 56.0%

dimethyl cyclohexane-1,3-dicarboxylate (62638-06-6) → cis-1,3-cyclohexanedicarboxylic acid monoester (25090-39-5,227783-07-5)

Guidance literature:

With barium dihydroxide; water;

DOI:10.1021/jo00281a043

Reference yield:

dimethyl cyclohexane-trans-1,3-dicarboxylate (10021-92-8) → trans-3-(methoxycarbonyl)cyclohexanecarboxylic acid (25090-39-5,227783-07-5)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01142a522

upstream raw materials:

dimethyl cyclohexane-1,3-dicarboxylate

cyclohexane-1,3-dicarboxylic acid

dimethyl cis-1,3-cyclohexanedicarboxylate

methanol

Downstream raw materials:

3-Carbomethoxy-cyclohexan-1-carbonylchlorid

methyl 3-(hydroxymethyl)cyclohexane-1-carboxylate

tert-butyl 3-(methoxycarbonyl)cyclohexanecarboxylate