1-Bromo-4-ethoxy-2,3-difluorobenzene

Base Information

• Chemical Name: 1-Bromo-4-ethoxy-2,3-difluorobenzene
• CAS No.: 156573-09-0
• Molecular Formula: C8H7BrF2O
• Molecular Weight: 237.044
• Hs Code.: 2909309090
• Mol file: 156573-09-0.mol

Synonyms:4-Bromo-2,3-difluorophenyl ethyl ether;

Chemical Property of 1-Bromo-4-ethoxy-2,3-difluorobenzene

Chemical Property:

• Vapor Pressure: 0.149mmHg at 25°C
• Melting Point: 31 °C
• Refractive Index: 1.497
• Boiling Point: 222.691 °C at 760 mmHg
• Flash Point: 107.235 °C
• PSA: 9.23000
• Density: 1.534 g/cm³
• LogP: 3.12600
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-4-ethoxy-2,3-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-4-ethoxy-2,3-difluorobenzene

There total 4 articles about 1-Bromo-4-ethoxy-2,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl bromide (74-96-4) + 2,3-difluoro-4-bromophenol (144292-32-0) → 1-bromo-4-ethoxy-2,3-difluorobenzene (156573-09-0)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; at 80 ℃; for 6h; Inert atmosphere;

Reference yield: 77.0%

diethyl sulfate (64-67-5) + 2,3-difluoro-4-bromophenol (144292-32-0) → 1-bromo-4-ethoxy-2,3-difluorobenzene (156573-09-0)

Guidance literature:

With potassium hydroxide; In water;

DOI:10.1055/s-0030-1260551

Reference yield:

ethyl bromide (74-96-4) → 1-bromo-4-ethoxy-2,3-difluorobenzene (156573-09-0)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In water;

upstream raw materials:

diethyl sulfate

2,3-difluoro-4-bromophenol

ethyl bromide

Downstream raw materials:

4-(1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-ethoxy-2,3-difluorophenyl)-cyclohexanol

1-(4-ethoxy-2,3-difluorophenyl)-4-vinylcyclohexanol

(4-ethoxy 2,3-difluorophenyl)boronic acid

C₂₁H₃₀F₂O

Refernces

• 1、 -. "LIQUID CRYSTALLINE COMPOUND WITH NEGATIVE DIELECTRIC ANISOTROPY, LIQUID CRYSTAL COMPOSITION USING SAME, AND LIQUID CRYSTAL DISPLAY ELEMENT". Page/Page column 37. . Retrieved 2012/08/14.
• 2、 -. "Trans-Monofluoroethylene Liquid Crystal Compound Having Negative Dielectric Anisotropy, A Liquid Crystal Composition Using The Compound And A Liquid Crystal Display Device". . . Retrieved 2011/12/13.