(R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Base Information

• Chemical Name: (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide
• CAS No.: 1259436-57-1
• Molecular Formula: C₁₄H₁₃NO₂S
• Molecular Weight: 259.329
• Mol file: 1259436-57-1.mol

Synonyms:(R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Chemical Property of (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

There total 6 articles about (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,2-benzoisothiazole 1,1-dioxide (5669-05-6) + 4-methylphenylboronic acid (5720-05-8) → (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide (1259436-57-1)

Guidance literature:

With nickel(II) perchlorate hexahydrate; (S)-2′-(tert-butyl)-7-(diphenylphosphino)-2,3-dihydro-5′H-spiro[indene-1,4′-oxazole]; In 2,2,2-trifluoroethanol; at 60 ℃; for 24h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2020.131201

Reference yield:

1,2-benzoisothiazole 1,1-dioxide (5669-05-6) + 4-methylphenylboronic acid (5720-05-8) → (S)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide (1166859-71-7) + (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide (1259436-57-1)

Guidance literature:

With potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; C₂₈H₂₆O₅S; In water; toluene; at 55 ℃; Overall yield = 92 percent; Overall yield = 71.5 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0037-1610749

Reference yield:

3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide (38938-54-4) → (S)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide (1166859-71-7) + (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide (1259436-57-1)

Guidance literature:

With Ru(OSO₂CF₃)(CH₃C₆H₄CH(CH₃)2)(NH₂CHC₆H₅CHC₆H₅NSO₂CH₃); hydrogen; In methanol; at 25 ℃; for 24h; under 37878.8 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1002/cjoc.201090260

upstream raw materials:

3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide

N-tert-butylbenzenesulfonamide

N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide

4-methyl-benzaldehyde