N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide

Base Information

• Chemical Name: N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide
• CAS No.: 1009806-74-9
• Molecular Formula: C₁₈H₂₃NO₃S
• Molecular Weight: 333.452
• Mol file: 1009806-74-9.mol

Synonyms:N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide

Chemical Property of N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide

There total 1 articles about N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-tert-butylbenzenesulfonamide (2512-24-5) + 4-methyl-benzaldehyde (104-87-0) → N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide (1009806-74-9)

Guidance literature:

N-tert-butylbenzenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;

4-methyl-benzaldehyde; In tetrahydrofuran; hexane; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane;

DOI:10.3987/COM-09-11884

Reference yield: 89.0%

N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide (1009806-74-9) → 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide (38938-59-9)

Guidance literature:

With chloro-trimethyl-silane; iodine; sodium iodide; In acetonitrile; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.3987/COM-09-11884

Reference yield:

N-t-butyl-2-[1-(4-methylphenyl)-1-hydroxymethyl]benzenesulfonamide (1009806-74-9) → N-tert-butyl-2-(4-methylbenzoyl)-benzenesulfonamide

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6cc09493g

upstream raw materials:

N-tert-butylbenzenesulfonamide

4-methyl-benzaldehyde

Downstream raw materials:

3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide

(S)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide

(R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide