Technology Process of (E)-3-ethoxy-N-(3-methoxy-4-nitro-phenyl)-acrylamide
There total 6 articles about (E)-3-ethoxy-N-(3-methoxy-4-nitro-phenyl)-acrylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,3-diethoxypropanoic acid;
With
thionyl chloride;
In
dichloromethane;
at 80 ℃;
for 1h;
3-methoxy-4-nitroanilin;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
With
hydrogenchloride;
In
water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / dmap / 62 h / 0 - 20 °C
2.1: nitric acid / 3 h / -15 - -10 °C
3.1: potassium carbonate / methanol / 3 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
5.1: hydrogenchloride / water / Reflux
6.1: thionyl chloride / dichloromethane / 1 h / 80 °C
6.2: 0 - 20 °C
6.3: 20 °C
With
pyridine; hydrogenchloride; thionyl chloride; nitric acid; potassium carbonate;
dmap;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid / 3 h / -15 - -10 °C
2.1: potassium carbonate / methanol / 3 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
4.1: hydrogenchloride / water / Reflux
5.1: thionyl chloride / dichloromethane / 1 h / 80 °C
5.2: 0 - 20 °C
5.3: 20 °C
With
hydrogenchloride; thionyl chloride; nitric acid; potassium carbonate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;