3-Methoxy-4-nitroaniline

Base Information

• Chemical Name: 3-Methoxy-4-nitroaniline
• CAS No.: 16292-88-9
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID00373125
• Nikkaji Number: J154.688K
• Wikidata: Q82161296
• Mol file: 16292-88-9.mol

Synonyms:3-methoxy-4-nitroaniline;16292-88-9;Benzenamine, 3-methoxy-4-nitro-;3-METHOXY-4-NITROBENZENAMINE;MFCD06661773;4-Nitro-m-anisidine;5-Amino-2-nitroanisole;SCHEMBL358064;3-methoxy-4-nitro-phenylamine;DTXSID00373125;AMY39256;CS-M0192;ZB0553;AKOS004910300;AS-10599;SY111706;FT-0713439;A22610;EN300-109120;3-methoxy-4-nitrobenzenamine;3-Methoxy-4-nitroaniline

Chemical Property of 3-Methoxy-4-nitroaniline

Chemical Property:

• Melting Point: 169°C
• Refractive Index: 1.6010 (estimate)
• Boiling Point: 337.07°C (rough estimate)
• PKA: 0.58±0.10(Predicted)
• PSA: 81.07000
• Density: 1.2089 (estimate)
• LogP: 2.29000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 168.05349212
• Heavy Atom Count: 12
• Complexity: 169

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-4-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)N)[N+](=O)[O-]

Technology Process of 3-Methoxy-4-nitroaniline

There total 15 articles about 3-Methoxy-4-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(3-methoxy-4-nitrophenyl)acetamide (20628-19-7) → 3-methoxy-4-nitroanilin (16292-88-9)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1021/jm00162a002

Reference yield: 55.0%

m-Anisidine (536-90-3,918666-97-4) → 3-methoxy-4-nitroanilin (16292-88-9) + 5-methoxy-2-nitroaniline (16133-49-6)

Guidance literature:

With bromine; silver nitrate; triphenylphosphine; In acetonitrile; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2006.07.054

Reference yield: 42.0%

m-Anisidine (536-90-3,918666-97-4) → 3-methoxy-4-nitroanilin (16292-88-9) + 5-methoxy-2-nitroaniline (16133-49-6) + 3-methoxy-2-nitroaniline (16554-47-5)

Guidance literature:

With sulfuric acid; uronium nitrate; at 0 - 4 ℃; for 1h;

DOI:10.1002/hlca.200490009

upstream raw materials:

N-(3-methoxy-4-nitrophenyl)acetamide

5-acetylamino-2-nitro-benzenesulfonic acid

2-Nitroanisole

3-methoxy-4-nitrobenzamide

Downstream raw materials:

3-methoxy-4-nitro-N-(methylsulfonyl)benzenamine

2,4,4'-Trichlor-3'-methoxydiphenyl-aether

4,4,4-trifluoro-3-hydroxy-N-(3-methoxy-4-nitrophenyl)nut-2-enamide

7-methoxy-4-hydroxy-6-nitroquinoline-3-carbonitrile