C₄₃H₄₅N₄O₉

Base Information

• Chemical Name: C₄₃H₄₅N₄O₉
• CAS No.: 1393486-78-6
• Molecular Formula: C₄₃H₄₅N₄O₉
• Molecular Weight: 761.852
• Mol file: 1393486-78-6.mol

Synonyms:C₄₃H₄₅N₄O₉

Chemical Property of C₄₃H₄₅N₄O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₄₅N₄O₉

There total 7 articles about C₄₃H₄₅N₄O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C22H29N4O7 (1393486-77-5) + 4,4'-dimethoxytrityl chloride (40615-36-9) → C43H45N4O9 (1393486-78-6)

Guidance literature:

C₂₂H₂₉N₄O₇; 4,4'-dimethoxytrityl chloride; With dmap; for 16h; Inert atmosphere;

With pyridine; for 4h; Inert atmosphere;

DOI:10.1021/jo301227w

Reference yield:

2'-O-methyluridine (2140-76-3) → C43H45N4O9 (1393486-78-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium azide / 1,2-dimethoxyethane; water / 0.25 h / 22 °C / Inert atmosphere

1.2: 24 h / 22 °C / Inert atmosphere

2.1: pyridine / 16 h / 0 - 22 °C / Inert atmosphere

3.1: triphenylphosphine; tetrachloromethane / dichloromethane / 2.5 h / Inert atmosphere; Reflux

4.1: triethylamine / dichloromethane / 16 h / 22 °C / Inert atmosphere

5.1: potassium fluoride / ethanol / 120 h / Inert atmosphere; Reflux

6.1: sodium hydrogencarbonate; dihydrogen peroxide; sodium tungstate / methanol / 30 h / 22 °C / Inert atmosphere

7.1: dmap / 16 h / Inert atmosphere

7.2: 4 h / Inert atmosphere

With pyridine; tetrachloromethane; dmap; potassium fluoride; sodium tungstate; sodium azide; dihydrogen peroxide; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

DOI:10.1021/jo301227w

Reference yield:

5-bromo-2'-O-methyluridine (34218-83-2) → C43H45N4O9 (1393486-78-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / 16 h / 0 - 22 °C / Inert atmosphere

2.1: triphenylphosphine; tetrachloromethane / dichloromethane / 2.5 h / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 16 h / 22 °C / Inert atmosphere

4.1: potassium fluoride / ethanol / 120 h / Inert atmosphere; Reflux

5.1: sodium hydrogencarbonate; dihydrogen peroxide; sodium tungstate / methanol / 30 h / 22 °C / Inert atmosphere

6.1: dmap / 16 h / Inert atmosphere

6.2: 4 h / Inert atmosphere

With pyridine; tetrachloromethane; dmap; potassium fluoride; sodium tungstate; dihydrogen peroxide; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In methanol; ethanol; dichloromethane;

DOI:10.1021/jo301227w

upstream raw materials:

C₂₂H₂₉N₄O₇

4,4'-dimethoxytrityl chloride

2'-O-methyluridine

5-bromo-2'-O-methyluridine

Downstream raw materials:

C₅₂H₆₄N₆O₁₀P