3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

Base Information

Chemical Name:3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide
CAS No.:1403259-27-7
Molecular Formula:C₂₅H₃₃BrN₄O₃
Molecular Weight:517.466
Hs Code.:

Synonyms:3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

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Chemical Property of 3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

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Technology Process of 3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

There total 4 articles about 3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403590-92-0
trans-3-((4-aminocyclohexyl)(methyl)amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-y|)methyl)-2-methylbenzamide

: 64-19-7,77671-22-8
acetic acid

: 1403259-27-7
3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1403258-26-3
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-amino)-2-methylbenzoate

: 1403259-27-7
3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / acetonitrile / 7 h / 80 °C

2.1: sodium hydroxide; water / methanol / 1 h / 60 °C

2.2: pH 4 - 6

3.1: dimethyl sulfoxide / 15 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.2: pH 8

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403259-27-7
3-(((1R,4R)-4-acetamidocyclohexyl)-(methyl)-amino)-5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)-methyl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / methanol / 8 h / 20 °C

3.2: 0 °C

4.1: caesium carbonate / acetonitrile / 7 h / 80 °C

5.1: sodium hydroxide; water / methanol / 1 h / 60 °C

5.2: pH 4 - 6

6.1: dimethyl sulfoxide / 15 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.2: pH 8

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

With water; iron; sodium carbonate; ammonium chloride; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;