2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone

Base Information

• Chemical Name: 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone
• CAS No.: 1380395-55-0
• Molecular Formula: C₁₇H₁₄N₂O₃S
• Molecular Weight: 326.376
• Mol file: 1380395-55-0.mol

Synonyms:2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone

Chemical Property of 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone

There total 6 articles about 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methylphenol (1357083-07-8) + α-bromoacetophenone (70-11-1) → 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone (1380395-55-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2012.03.061

Reference yield:

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methylphenol (1357083-07-8) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone (1380395-55-0)

Guidance literature:

In ethanol; at 20 ℃;

Reference yield:

2-hydroxy-p-toluic acid (50-85-1) → 2-(5-(2-hydroxy-4-methylphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone (1380395-55-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / Reflux

2.1: hydrazine hydrate / ethanol / Reflux

3.1: potassium hydroxide / ethanol / 24 h / Reflux

3.2: pH 5 - 6

4.1: sodium hydroxide / ethanol; water / 20 °C

With sulfuric acid; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1016/j.bmc.2012.03.061

upstream raw materials:

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methylphenol

α-bromoacetophenone

2-hydroxy-p-toluic acid

methyl 2-hydroxy-4-methylbenzoate