3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Base Information

• Chemical Name: 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
• CAS No.: 1228779-96-1
• Molecular Formula: C₁₂H₁₇N₃O₅S
• Molecular Weight: 315.35
• Hs Code.: 2932990090
• Mol file: 1228779-96-1.mol

Synonyms:3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide

Chemical Property of 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Chemical Property:

• Melting Point: 188 - 191°C
• Boiling Point: 542.0±60.0 °C(Predicted)
• PKA: 9.58±0.60(Predicted)
• Density: 1.412±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-?Nitro-?4-?(((tetrahydro-?2H-?pyran-?4-?yl)?methyl)?amino)?benzenesulfonamide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors.

Technology Process of 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

There total 6 articles about 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-tetrahydropyranmethylamine (130290-79-8) + 4-fluoro-3-nitrobenzenesulfonamide (406233-31-6) → 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide (1228779-96-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield: 91.0%

4-tetrahydropyranmethylamine (130290-79-8) + 4-Chloro-3-nitrobenzenesulfonamide (97-09-6) → 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide (1228779-96-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 12h;

Reference yield:

tetrahydro-2H-pyran-4-carbonitrile (4295-99-2) → 3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide (1228779-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; ammonia / methanol / 12 h / 40 - 45 °C / 3000.3 - 3750.38 Torr

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 25 h / 55 - 70 °C

With ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;

upstream raw materials:

4-tetrahydropyranmethylamine

4-fluoro-3-nitrobenzenesulfonamide

4-Chloro-3-nitrobenzenesulfonamide

tetrahydro-2H-pyran-4-carbonitrile

Downstream raw materials:

4-{4-[(4′-chloro-1,1′-biphenyl-2-yl)methyl]piperazin-1-yl}-N-({3-nitro-4-[(tetra-hydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-phenoxybenzamide

4-(4-((4'-chloro-1,1'-biphenyl-2-yl)methyl)piperazin-1-yl)-2-(3-((dimethylamino)methyl)phenoxy)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)benzamide

2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide

4-{4-[(4′-chloro-1,1′-biphenyl-2-yl)methyl]piperazin-1-yl}-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1228779-96-1 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide

Send

Send

Metric Ton KG G Pound L ML

Send

Send