Technology Process of 4-hydroxy-N-methyl-N-(methylsulfonyl)-N',4-diphenylbut-2-ynimidamide
There total 9 articles about 4-hydroxy-N-methyl-N-(methylsulfonyl)-N',4-diphenylbut-2-ynimidamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-methyl-N-(methylsulfonyl)-N'-phenylpropiolimidamide; benzaldehyde;
With
trimethylsilyl trifluoromethanesulfonate; diisopropylamine; zinc dibromide;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
Sealed tube;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; dichloromethane;
at 28 ℃;
for 0.5h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/ja412634w
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; silver nitrate / acetone / 1 h / 20 °C / Inert atmosphere
2.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / toluene / 80 °C / Inert atmosphere; Sealed tube
3.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere
4.1: diisopropylamine; zinc dibromide; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Sealed tube
4.2: 0.5 h / 28 °C / Inert atmosphere; Sealed tube
With
N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; zinc trifluoromethanesulfonate; potassium carbonate; silver nitrate; diisopropylamine; zinc dibromide;
In
dichloromethane; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1021/ja412634w
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / toluene / 80 °C / Inert atmosphere; Sealed tube
2.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere
3.1: diisopropylamine; zinc dibromide; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Sealed tube
3.2: 0.5 h / 28 °C / Inert atmosphere; Sealed tube
With
1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; zinc trifluoromethanesulfonate; potassium carbonate; diisopropylamine; zinc dibromide;
In
dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ja412634w
