Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester

Base Information

• Chemical Name: Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester
• CAS No.: 138499-08-8
• Molecular Formula: C9H11NO6
• Molecular Weight: 229.189
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10459464
• Wikidata: Q82283237
• Mol file: 138499-08-8.mol

Synonyms:138499-08-8;Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester;(2,5-dioxopyrrolidin-1-yl) [(3S)-oxolan-3-yl] Carbonate;SCHEMBL469669;DTXSID10459464;AKOS030241068;(3S)-TETRAHYDROFURANYLSUCCINIMIDYL-CARBONATE;J-007143;(s)-2,5-dioxopyrrolidin-1-yl tetrahydrofuran-3-yl carbonate;2,5-dioxo-1-pyrrolidinyl [(3S)tetrahydro-3-furanyl] carbonate;1-[({[(3S)-Oxolan-3-yl]oxy}carbonyl)oxy]pyrrolidine-2,5-dione;1-([(35)tetrahydro-3-furanyloxy]carbonyloxy)dihydro-1H-pyrrole-2,5-dione;1-([(3S)tetrahydro-3-furanyloxy]carbonyloxy)dihydro-1H-pyrrole-2,5-dione;1-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}oxy)pyrrolidine-2,5-dione;(3S)-Carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester tetrahydrofuran-3-yl ester

Chemical Property of Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 9.63E-05mmHg at 25°C
• Melting Point: 114-117°C
• Refractive Index: 1.536
• Boiling Point: 338.736 °C at 760 mmHg
• Flash Point: 158.662 °C
• PSA: 82.14000
• Density: 1.457 g/cm³
• LogP: -0.06960
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Ether, Methanol
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 229.05863707
• Heavy Atom Count: 16
• Complexity: 312

Purity/Quality:

99%, ^*data from raw suppliers

CarbonicAcid2,5-Dioxopyrrolidin-1-yl(S)-Tetrahydrofuran-3-ylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCC1OC(=O)ON2C(=O)CCC2=O
• Isomeric SMILES: C1COC[C@H]1OC(=O)ON2C(=O)CCC2=O
• Uses: Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester (cas# 138499-08-8) is a compound useful in organic synthesis.

Technology Process of Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester

There total 3 articles about Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di(succinimido) carbonate (74124-79-1) + (S)-3-hydroxytetyrahydrofurane (86087-23-2,84921-89-1,864447-89-2) → 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione (138499-08-8)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

phosgene (75-44-5) + 1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (S)-3-hydroxytetyrahydrofurane (86087-23-2,84921-89-1,864447-89-2) → 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione (138499-08-8)

Guidance literature:

With triethylamine; In ethyl acetate; toluene;

Reference yield:

→ 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione (138499-08-8)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 18h;

upstream raw materials:

di(succinimido) carbonate

(S)-3-hydroxytetyrahydrofurane

phosgene

1-hydroxy-pyrrolidine-2,5-dione

Downstream raw materials:

(R)-2-((2S,5'S)-5'-Benzyl-5'-{(2S,3S)-2-hydroxy-4-phenyl-3-[(S)-(tetrahydro-furan-3-yl)oxycarbonylamino]-butyl}-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl)-3-phenyl-propionic acid methyl ester

{(1S,2S)-1-Benzyl-3-[(2S,5'S)-5'-benzyl-4-((R)-1-carbamoyl-2-phenyl-ethyl)-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-5'-yl]-2-hydroxy-propyl}-carbamic acid (S)-(tetrahydro-furan-3-yl) ester

{(1S,2S)-1-Benzyl-3-[(2S,5'S)-5'-benzyl-4-((R)-1-tert-butylcarbamoyl-2-phenyl-ethyl)-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-5'-yl]-2-hydroxy-propyl}-carbamic acid (S)-(tetrahydro-furan-3-yl) ester

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