ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

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Chemical Name:ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate
CAS No.:944332-06-3
Molecular Formula:C₃₃H₃₀F₃NO₆
Molecular Weight:593.6
Hs Code.:

Synonyms:ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

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Chemical Property of ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

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Technology Process of ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

There total 7 articles about ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 944331-26-4
2-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 944334-70-7
ethyl 1-benzyloxymethyl-5-bromo-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

: 944332-06-3
ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

Guidance literature:: With potassium phosphate; palladium diacetate; catacxium A; In water; toluene; at 100 ℃; for 2h;

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 944332-06-3
ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

2: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / water; toluene / 3 h / 20 °C

3: dimethyl zinc(II) / toluene / 28.25 h / -40 - 20 °C

4: boron tribromide / dichloromethane / 0.5 h / -70 - 0 °C

5: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

6: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

7: potassium phosphate / palladium diacetate; catacxium A / water; toluene / 2 h / 100 °C

With sodium hydroxide; potassium phosphate; dimethyl zinc(II); potassium acetate; boron tribromide; potassium carbonate; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; tetra(n-butyl)ammonium hydrogensulfate; catacxium A; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 7: Suzuki Coupling;

Reference yield:

: 485402-61-7
4-bromo-(2-cyclopropyloxy)phenol

: 944332-06-3
ethyl 1-benzyloxymethyl-5-(3-cyclopropoxy-4-difluoromethoxyphenyl)-4-(2-fluorobenzyl)-2-formyl-1H-pyrrol-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrabutylammomium bromide / water; toluene / 0.5 h / 80 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 80 °C

3: potassium phosphate / palladium diacetate; catacxium A / water; toluene / 2 h / 100 °C

With sodium hydroxide; potassium phosphate; potassium acetate; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; catacxium A; In 1,4-dioxane; water; toluene; 3: Suzuki Coupling;