tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate
CAS No.:1622096-30-3
Molecular Formula:C₂₉H₄₇NO₇Si
Molecular Weight:549.78
Hs Code.:

Synonyms:tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

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Chemical Property of tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

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Technology Process of tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

There total 11 articles about tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: N-[2-[(5S,6R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-hydroxy-1-cyclohexen-1-yl]ethyl]-N-methyl-carbamic acid 1,1-dimethylethyl ester

: 65299-00-5
3-hydroxy-4-(methoxymethoxy)benzaldehyde

: 1622096-30-3
tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; at -10 - 20 ℃; for 18h;
DOI:10.1002/anie.201400286

Reference yield:

: 65298-95-5
3-Acetoxy-4-(methoxymethoxy)benzaldehyd

: 1622096-30-3
tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; methanol / 0.67 h / 20 °C

2: tributylphosphine; diamide / tetrahydrofuran / 18 h / -10 - 20 °C

With methanol; tributylphosphine; diamide; potassium carbonate; In tetrahydrofuran; 2: |Mitsunobu Displacement;
DOI:10.1002/anie.201400286

Reference yield:

: 103-63-9
1-phenyl-2-bromoethane

: 1622096-30-3
tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: E_. coli JM 109 (pDTG₆₀₁A)

2: potassium diazodicarboxylate; acetic acid / methanol / 0 °C

3: toluene-4-sulfonic acid / acetone

4: potassium carbonate / tetrahydrofuran / Sealed tube

5: hydrogenchloride / ethanol

6: sodium hydrogencarbonate / ethanol

7: 1H-imidazole / dichloromethane / -78 - 20 °C

8: tributylphosphine; diamide / tetrahydrofuran / 18 h / -10 - 20 °C

With 1H-imidazole; hydrogenchloride; tributylphosphine; diamide; potassium diazodicarboxylate; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone; 8: |Mitsunobu Displacement;
DOI:10.1002/anie.201400286