65298-95-5

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 65299-01-6 acetic acid 2-benzyloxy-5-formylphenyl ester 
• 65298-99-9 acetic acid 5-formyl-2-hydroxy-phenyl ester 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 1622096-30-3 tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate 
• 1622096-31-4 N-(2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(5-formyl-2-(methoxymethoxy)phenoxy)cyclohex-1-en-1-yl)ethyl)-N,4-dimethylbenzenesulfonamide 
• 65299-00-5 3-hydroxy-4-(methoxymethoxy)benzaldehyde 

Relevant academic research and scientific papers

PROCESS FOR PREPARING MORPHINE COMPOUNDS

The present application relates to processes for the preparation of morphine compounds utilizing a novel intramolecular [4+2] cycloaddition reaction.

Short chemoenzymatic total synthesis of ent-hydromorphone: An oxidative dearomatization/intramolecular [4+2] cycloaddition/amination sequence

A short synthesis of ent-hydromorphone has been achieved in twelve steps from β-bromoethylbenzene. The key transformations involved the enzymatic dihydroxylation of the arene to the corresponding cis-dihydrodiol, Mitsunobu coupling with the ring?A fragmen