N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

Base Information

Chemical Name:N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester
CAS No.:945245-46-5
Molecular Formula:C₂₆H₂₄BrNO₄
Molecular Weight:494.385
Hs Code.:

Synonyms:N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

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Chemical Property of N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

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Technology Process of N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

There total 8 articles about N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 945245-45-4
N-(fluorenyl-9-methoxycarbonyl)-L-(p-hydroxymethyl)phenylalanine methyl ester

: 945245-46-5
N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tet.2007.03.028

Reference yield:

: 298693-92-2
N-(fluorenyl-9-methoxycarbonyl)-L-O-trifluoromethylsulfonyl-tyrosine methyl ester

: 945245-46-5
N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-bis-(diphenylphosphino)-propane; triethylamine / Pd(OAc)2 / dimethylformamide / 0.17 h

1.2: 40 percent / trioctylsilane / dimethylformamide / 12 h / 70 °C

2.1: 72 percent / sodium borohydride / CH₂Cl₂; methanol / 0.67 h / 20 °C

3.1: 83 percent / triphenylphosphine; N-bromo-succinimide / tetrahydrofuran / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.028

Reference yield:

: 82911-79-3
N-(fluorenyl-9-methoxycarbonyl)-L-tyrosine methyl ester

: 945245-46-5
N-(fluorenyl-9-methoxycarbonyl)-L-(p-bromomethyl)phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81 percent / pyridine / CH₂Cl₂ / 0.67 h / 0 - 5 °C

2.1: 1,3-bis-(diphenylphosphino)-propane; triethylamine / Pd(OAc)2 / dimethylformamide / 0.17 h

2.2: 40 percent / trioctylsilane / dimethylformamide / 12 h / 70 °C

3.1: 72 percent / sodium borohydride / CH₂Cl₂; methanol / 0.67 h / 20 °C

4.1: 83 percent / triphenylphosphine; N-bromo-succinimide / tetrahydrofuran / 0 - 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; triethylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.028