1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

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Chemical Name:1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole
CAS No.:821004-44-8
Molecular Formula:C₂₁H₁₇N₅O₅
Molecular Weight:419.396
Hs Code.:

Synonyms:1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

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Chemical Property of 1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

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Technology Process of 1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

There total 6 articles about 1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 67-56-1
methanol

: 821004-42-6
1-benzyl-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole-2-carboxylic acid

: 821004-44-8
1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

Guidance literature:: 1-benzyl-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole-2-carboxylic acid; With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.16667h;

methanol; at 65 ℃; for 1.16667h;
DOI:10.3987/com-04-10144

Reference yield:

: ethyl 1-benzyl-3-cyano-1H-pyrrole-2-carboxylate

: 821004-44-8
1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / ammonia (liquid) / 96 h / 100 °C

2.1: 93 percent / sodium methoxide; hydroxylamine sulfate / methanol / 18 h / Heating

3.1: 54 percent / triethylamine / tetrahydrofuran / 5 h / 20 °C

4.1: 55 percent / acetic acid / toluene / 16 h / Heating

5.1: 57 percent / nitrosylsulfuric acid / acetic acid / 20 °C

6.1: triethylamine; diphenylphosphoryl azide / dimethylformamide / 1.17 h / 20 °C

6.2: 46 percent / 1.17 h / 65 °C

With nitrosylsulfuric acid; diphenylphosphoranyl azide; ammonia; sodium methylate; hydroxylamine sulfate; acetic acid; triethylamine; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.3987/com-04-10144

Reference yield:

: 821004-36-8
1-benzyl-3-cyanopyrrole-2-carboxamide

: 821004-44-8
1-benzyl-2-methoxycarbonylamino-3-[5-(p-nitrophenyl)-1,2,4-oxadiazol-3-yl]pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / sodium methoxide; hydroxylamine sulfate / methanol / 18 h / Heating

2.1: 54 percent / triethylamine / tetrahydrofuran / 5 h / 20 °C

3.1: 55 percent / acetic acid / toluene / 16 h / Heating

4.1: 57 percent / nitrosylsulfuric acid / acetic acid / 20 °C

5.1: triethylamine; diphenylphosphoryl azide / dimethylformamide / 1.17 h / 20 °C

5.2: 46 percent / 1.17 h / 65 °C

With nitrosylsulfuric acid; diphenylphosphoranyl azide; sodium methylate; hydroxylamine sulfate; acetic acid; triethylamine; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.3987/com-04-10144