(R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate
CAS No.:157007-54-0
Molecular Formula:C10H19NO2
Molecular Weight:185.266
Hs Code.:2933998090
European Community (EC) Number:633-899-9
DSSTox Substance ID:DTXSID70364025
Nikkaji Number:J2.316.287C
Wikidata:Q72497185
Mol file:157007-54-0.mol

Synonyms:157007-54-0;(R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate;(R)-1-BOC-2-METHYL-PYRROLIDINE;tert-butyl (2R)-2-methylpyrrolidine-1-carboxylate;(R)-1-Boc-2-methylpyrrolidine;(R)-N-Boc-2-methylpyrrolidine;(R)-tert-Butyl2-methylpyrrolidine-1-carboxylate;SCHEMBL178721;TERT-BUTYL (R)-2-METHYLPYRROLIDINE-1-CARBOXYLATE;DTXSID70364025;MFCD09261335;AKOS016843820;(R)-1-Boc-2-methylpyrrolidine, 97%;AS-36975;A3452;CS-0079676;(R)-(-)-1-BOC-2-METHYLPYRROLIDINE;(R)-(-)-1-Boc-2-methylpyrrolidine, 96+%;(2R)-1-(tert-Butyloxycarbonyl)-2-methylpyrrolidine;J-009364;2-(R)-methyl-pyrrolidine-1-carboxylic Tert-butyl Ester;1-Pyrrolidinecarboxylicacid,2-methyl-,1,1-dimethylethyl ester,(2R)-

Suppliers and Price of (R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-1-Boc-2-methyl-pyrrolidine
500mg
$ 110.00

Sigma-Aldrich
(R)-1-Boc-2-methylpyrrolidine 97%
1g
$ 94.40

Crysdot
(R)-tert-Butyl2-methylpyrrolidine-1-carboxylate 95+%
25g
$ 653.00

Crysdot
(R)-tert-Butyl2-methylpyrrolidine-1-carboxylate 95+%
10g
$ 363.00

Chem-Impex
(R)-1-Boc-2-methylpyrrolidine,97% 97%
1G
$ 92.96

Chemenu
(R)-tert-Butyl2-methylpyrrolidine-1-carboxylate 95%
10g
$ 343.00

Chemenu
(R)-tert-Butyl2-methylpyrrolidine-1-carboxylate 95%
25g
$ 617.00

American Custom Chemicals Corporation
(R)-1-BOC-2-METHYL-PYRROLIDINE 95.00%
1G
$ 723.52

American Custom Chemicals Corporation
(R)-1-BOC-2-METHYL-PYRROLIDINE 95.00%
250MG
$ 135.89

AK Scientific
(R)-1-Boc-2-Methyl-pyrrolidine
25g
$ 1842.00

Total 32 raw suppliers

Chemical Property of (R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate

Chemical Property:

Refractive Index:n20/D 1.447
Boiling Point:234 °C at 760 mmHg
PKA:-1.21±0.40(Predicted)
Flash Point:95.3 °C
PSA：29.54000
Density:0.99 g/cm³
LogP:2.34370
Storage Temp.:2-8°C
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:185.141578849
Heavy Atom Count:13
Complexity:196

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Boc-2-methyl-pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): C, F, Xi
Hazard Codes:C,F,Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCCN1C(=O)OC(C)(C)C
Isomeric SMILES:C[C@@H]1CCCN1C(=O)OC(C)(C)C

Technology Process of (R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate

There total 10 articles about (R)-tert-Butyl 2-methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 338945-22-5,177750-73-1
(S)-2-iodomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 157007-54-0
2-(R)-methylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; at 20 ℃;
DOI:10.1016/j.tet.2006.02.046

Reference yield: 85.0%

: 132482-09-8
tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate

: 157007-54-0
2-(R)-methylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;
DOI:10.1002/psc.3228

Reference yield:

: 77-78-1
dimethyl sulfate

: N-(tert-butoxycarbonyl)-2-trimethylstannylpyrrolidine

: 137496-71-0
2-methylpyrrolidine-1-carboxylic acid tert-butyl ester

: 157007-54-0
2-(R)-methylpyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: N-(tert-butoxycarbonyl)-2-trimethylstannylpyrrolidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

dimethyl sulfate; In tetrahydrofuran; hexane; at -78 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja002662u