2-bromo-N-(4-fluorobenzyl)benzamide

Base Information

• Chemical Name: 2-bromo-N-(4-fluorobenzyl)benzamide
• CAS No.: 425608-17-9
• Molecular Formula: C₁₄H₁₁BrFNO
• Molecular Weight: 308.15
• Mol file: 425608-17-9.mol

Synonyms:C₁₄H₁₁BrFNO

Chemical Property of 2-bromo-N-(4-fluorobenzyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-N-(4-fluorobenzyl)benzamide

There total 2 articles about 2-bromo-N-(4-fluorobenzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

para-fluorobenzylamine (140-75-0) + 2-bromobenzoic-acid (88-65-3) → C14H11BrFNO (425608-17-9)

Guidance literature:

2-bromobenzoic-acid; With triethylamine; isobutyl chloroformate; In dichloromethane; for 0.25h; Inert atmosphere; Schlenk technique;

para-fluorobenzylamine; In dichloromethane; at 0 ℃;

DOI:10.1002/ejoc.201501170

Reference yield: 70.0%

2-bromobenzoic acid chloride (7154-66-7) + para-fluorobenzylamine (140-75-0) → C14H11BrFNO (425608-17-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.mcat.2021.111766

Reference yield: 80.0%

C14H11BrFNO (425608-17-9) → 5-(4-fluorobenzyl)phenanthridin-6(5H)-one

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; cesium fluoride; In N,N-dimethyl acetamide; water; at 140 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.201501170

upstream raw materials:

para-fluorobenzylamine

2-bromobenzoic-acid

2-bromobenzoic acid chloride

Downstream raw materials:

C₁₄H₁₀FNOS