(2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

Base Information

Chemical Name:(2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone
CAS No.:863398-84-9
Molecular Formula:C₂₂H₄₂O₃Si
Molecular Weight:382.659
Hs Code.:

Synonyms:(2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

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Chemical Property of (2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

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Technology Process of (2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

There total 1 articles about (2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 930-68-7
cyclohexenone

: 73448-13-2
tert-butyldimethylsilyl hex-5-yn-1-yl ether

: 123-72-8
butyraldehyde

: 863398-84-9
(2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

Guidance literature:: tert-butyldimethylsilyl hex-5-yn-1-yl ether; With Schwartz's reagent; In tetrahydrofuran; at 25 ℃; for 0.5h;

cyclohexenone; butyraldehyde; With (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In tetrahydrofuran; at 25 ℃; for 12h;
DOI:10.1002/anie.200500789

Reference yield:

: 863398-84-9
(2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

: 124-63-0
methanesulfonyl chloride

: Methanesulfonic acid 1-{(1S,2R)-2-[(E)-6-(tert-butyl-dimethyl-silanyloxy)-hex-1-enyl]-6-oxo-cyclohexyl}-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 0.5h;
DOI:10.1002/anie.200500789

Reference yield:

: 863398-84-9
(2S,3R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-(1-hydroxy-butyl)-cyclohexanone

: (R)-3-[(E)-6-(tert-Butyl-dimethyl-silanyloxy)-hex-1-enyl]-2-but-(E)-ylidene-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / 0 - 25 °C

2: basic alumina / CH₂Cl₂ / 12 h / 25 °C

With aluminum oxide; triethylamine; In dichloromethane;
DOI:10.1002/anie.200500789