O-benzyl tert-butyl glyoxylate oxime ether

Base Information

• Chemical Name: O-benzyl tert-butyl glyoxylate oxime ether
• CAS No.: 203127-16-6
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.283
• Mol file: 203127-16-6.mol

Synonyms:O-benzyl tert-butyl glyoxylate oxime ether

Chemical Property of O-benzyl tert-butyl glyoxylate oxime ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-benzyl tert-butyl glyoxylate oxime ether

There total 3 articles about O-benzyl tert-butyl glyoxylate oxime ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

tert-butyl glyoxylate (7633-32-1) + O-benzylhydoxylamine hydrochloride (2687-43-6) → O-benzyl tert-butyl glyoxylate oxime ether (203127-16-6)

Guidance literature:

In pyridine; dichloromethane; for 2.5h; Ambient temperature;

DOI:10.1021/jo972302y

Reference yield:

di-tert-butyl fumarate (7633-38-7) + O-benzylhydoxylamine hydrochloride (2687-43-6) → O-benzyl tert-butyl glyoxylate oxime ether (203127-16-6)

Guidance literature:

di-tert-butyl fumarate; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

O-benzylhydoxylamine hydrochloride; With pyridine; In ethanol; for 0.666667h; Heating;

DOI:10.1039/b402764g

Reference yield:

di-tert-butyl fumarate (7633-38-7) → O-benzyl tert-butyl glyoxylate oxime ether (203127-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) O₃, O₂, 2.) Me₂S / 1.) CH₂Cl₂, -23 deg C, 4.5 h, 2.) CH₂Cl₂, 0 deg C to rt

2: 60 percent / pyridine; CH₂Cl₂ / 2.5 h / Ambient temperature

With dimethylsulfide; oxygen; ozone; In pyridine; dichloromethane;

DOI:10.1021/jo972302y

upstream raw materials:

tert-butyl glyoxylate

O-benzylhydoxylamine hydrochloride

di-tert-butyl fumarate

Downstream raw materials:

N-benzyloxy-L-allylglycine tert-butyl ester

N-benzyloxy-4-methylene-L-glutamic acid di-tert-butyl ester