11,13-O-isopropylidene-podophyllol

Base Information

Chemical Name:11,13-O-isopropylidene-podophyllol
CAS No.:683805-24-5
Molecular Formula:C₂₅H₃₀O₈
Molecular Weight:458.508
Hs Code.:

Synonyms:11,13-O-isopropylidene-podophyllol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 11,13-O-isopropylidene-podophyllol

Chemical Property:

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Technology Process of 11,13-O-isopropylidene-podophyllol

There total 3 articles about 11,13-O-isopropylidene-podophyllol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 77-76-9
2,2-dimethoxy-propane

: 78339-51-2
podophyllol

: 683805-24-5
11,13-O-isopropylidene-podophyllol

: 683805-22-3
4,11-O-isopropylidene-podophyllol

: 683805-23-4
(4aR,5R,6R,11bR)-5-(1-Methoxy-1-methyl-ethoxymethyl)-2,2-dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthrene

Guidance literature:: With toluene-4-sulfonic acid; at 20 ℃; for 7h;
DOI:10.1016/j.tet.2004.01.017

Reference yield: 54.0%

: 77-76-9
2,2-dimethoxy-propane

: 78339-51-2
podophyllol

: 683805-24-5
11,13-O-isopropylidene-podophyllol

: 683805-22-3
4,11-O-isopropylidene-podophyllol

Guidance literature:: 2,2-dimethoxy-propane; podophyllol; With toluene-4-sulfonic acid; at 20 ℃; for 3.5h;

With triethylamine; In methanol; water; at 60 ℃; for 8h; Further stages.;
DOI:10.1016/j.tet.2004.01.017

Reference yield:

: 518-28-5
podofilox

: 683805-24-5
11,13-O-isopropylidene-podophyllol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / LAH / tetrahydrofuran / 2.5 h / 0 °C

2.1: p-toluenesulfonic acid monohydrate / 3.5 h / 20 °C

2.2: 15 percent / Et₃N / methanol; H₂O / 8 h / 60 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1016/j.tet.2004.01.017