ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

Base Information

Chemical Name:ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate
CAS No.:1423027-23-9
Molecular Formula:C₁₈H₂₅F₂NO₅
Molecular Weight:373.397
Hs Code.:

Synonyms:ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

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Chemical Property of ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

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Technology Process of ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

There total 4 articles about ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 1423027-21-7
ethyl [(1H-benzotriazol-1-ylmethyl)(4-methoxybenzyl)amino]propanoate

: 1423027-23-9
ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

Guidance literature:: Ethyl bromodifluoroacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

ethyl [(1H-benzotriazol-1-ylmethyl)(4-methoxybenzyl)amino]propanoate; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.12.115

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1423027-23-9
ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 16 h / 0 - 20 °C

2.1: methanol / 16 h / 20 °C

3.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; zinc; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.tetlet.2012.12.115

Reference yield:

: 67044-04-6
ethyl 3-[(4-methoxybenzyl)amino]propanoate

: 1423027-23-9
ethyl 3-[(3-ethoxy-3-oxopropyl)(4-methoxybenzyl)amino]-2,2-difluoropropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 16 h / 20 °C

2.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; zinc; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2012.12.115