Technology Process of 1,2-cis-2,3-trans-3,4-trans-2-(2-propen-1-yl)-3-ethoxycarbonyl-cyclopentan-4-benzoyloxy-1-ol-1-THP
There total 11 articles about 1,2-cis-2,3-trans-3,4-trans-2-(2-propen-1-yl)-3-ethoxycarbonyl-cyclopentan-4-benzoyloxy-1-ol-1-THP which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / K2CO3 / dimethylformamide / Ambient temperature
2: 97 percent / n-butyllithium, diisopropylamide, / hexane; tetrahydrofuran / 1 h / Ambient temperature
3: 70 percent / p-toluenesulfonic acid / benzene / Heating
4: 50percent sulfuric acid, silica gel / CH2Cl2 / 5 h / Ambient temperature
5: 70 percent / K-Selectride / tetrahydrofuran / 4 h / -78 °C
6: 94 percent / sulfuric acid, silica gel / CH2Cl2 / 30 h
7: PPTS / CH2Cl2 / 4 h / Ambient temperature
8: 93 percent / NaBH4 / ethanol; H2O / 1 h / 0 °C
9: 85 percent / triethylamine, DMAP / CH2Cl2 / 1.5 h / 0 °C
With
dmap; sodium tetrahydroborate; n-butyllithium; sulfuric acid; pyridinium p-toluenesulfonate; silica gel; potassium tri-sec-butyl-borohydride; potassium carbonate; triethylamine; diisopropylamine;
toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)91299-2
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / K2CO3 / dimethylformamide / Ambient temperature
2: 97 percent / n-butyllithium, diisopropylamide, / hexane; tetrahydrofuran / 1 h / Ambient temperature
3: 70 percent / p-toluenesulfonic acid / benzene / Heating
4: 50percent sulfuric acid, silica gel / CH2Cl2 / 5 h / Ambient temperature
5: 70 percent / K-Selectride / tetrahydrofuran / 4 h / -78 °C
6: 94 percent / sulfuric acid, silica gel / CH2Cl2 / 30 h
7: PPTS / CH2Cl2 / 4 h / Ambient temperature
8: 93 percent / NaBH4 / ethanol; H2O / 1 h / 0 °C
9: 85 percent / triethylamine, DMAP / CH2Cl2 / 1.5 h / 0 °C
With
dmap; sodium tetrahydroborate; n-butyllithium; sulfuric acid; pyridinium p-toluenesulfonate; silica gel; potassium tri-sec-butyl-borohydride; potassium carbonate; triethylamine; diisopropylamine;
toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)91299-2
