(R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

Base Information

Chemical Name:(R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate
CAS No.:1648743-95-6
Molecular Formula:C₃₄H₃₁N₃O₄
Molecular Weight:545.638
Hs Code.:

Synonyms:(R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

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Chemical Property of (R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

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Technology Process of (R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

There total 8 articles about (R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1041482-25-0
dibenzyl (2,2-diphenylpent-4-en-1-yl)amino-methylylidenebiscarbamate

: 1648743-95-6
(R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

Guidance literature:: dibenzyl (2,2-diphenylpent-4-en-1-yl)amino-methylylidenebiscarbamate; With (S)-hydroxy(4-methylbenzenesulfonato-κO)[2-(1-methoxyethyl)phenyl]iodine; In acetonitrile; at -48 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

With trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; In acetonitrile; at -48 ℃; for 5h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201403891

Reference yield:

: 1041482-25-0
dibenzyl (2,2-diphenylpent-4-en-1-yl)amino-methylylidenebiscarbamate

: 1648743-95-6
(R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

: 1648743-96-7
(S)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

Guidance literature:: With sodium perborate tetrahydrate; (R)-2-((2-iodophenyl)(methoxy)methyl)pyridine; acetic acid; In acetonitrile; at 25 ℃; for 5h; Overall yield = 69 %; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201403891

Reference yield:

: 53001-06-2
2,2-diphenyl-4-pentenylamine

: 1648743-95-6
(R)-benzyl 3-(benzyloxycarbonylimino)-6,6-diphenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-2(3H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere; Schlenk technique

2.1: (S)-hydroxy(4-methylbenzenesulfonato-κO)[2-(1-methoxyethyl)phenyl]iodine / acetonitrile / 0.08 h / -48 °C / Inert atmosphere; Schlenk technique

2.2: 5 h / -48 °C / Inert atmosphere; Schlenk technique

With triethylamine; (S)-hydroxy(4-methylbenzenesulfonato-κO)[2-(1-methoxyethyl)phenyl]iodine; In dichloromethane; acetonitrile;
DOI:10.1002/chem.201403891