Technology Process of C26H27F2NO3
There total 16 articles about C26H27F2NO3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: 1 h / 0 - 20 °C
2.1: nitric acid; acetic acid; sulfuric acid / 1 h / 0 - 20 °C
3.1: palladium 10% on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C
4.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
4.2: 2 h / 100 °C
5.1: dmap; triethylamine / N,N-dimethyl-formamide / 50 °C
6.1: hydrazine hydrate / tert-butyl alcohol / 110 °C / Inert atmosphere
7.1: trifluoroacetic acid / dichloromethane / 20 °C
8.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C
9.1: borane-THF / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere
10.1: caesium carbonate / butanone / 0.5 h / 20 °C
10.2: 3 h / 20 °C
11.1: water; sodium hydroxide / tetrahydrofuran / 1 h / 20 °C
12.1: thionyl chloride / 2 h / Reflux
With
dmap; thionyl chloride; borane-THF; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; nitric acid; sodium hydrogencarbonate; caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; butanone; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: nitric acid; acetic acid; sulfuric acid / 1 h / 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / ethanol; methanol; acetic acid / 36 h / 20 °C
3.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
3.2: 2 h / 100 °C
4.1: dmap; triethylamine / N,N-dimethyl-formamide / 50 °C
5.1: hydrazine hydrate / tert-butyl alcohol / 110 °C / Inert atmosphere
6.1: trifluoroacetic acid / dichloromethane / 20 °C
7.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 20 °C
8.1: borane-THF / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere
9.1: caesium carbonate / butanone / 0.5 h / 20 °C
9.2: 3 h / 20 °C
10.1: water; sodium hydroxide / tetrahydrofuran / 1 h / 20 °C
11.1: thionyl chloride / 2 h / Reflux
With
dmap; thionyl chloride; borane-THF; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; nitric acid; sodium hydrogencarbonate; caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; butanone; tert-butyl alcohol;