cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide

Base Information

• Chemical Name: cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide
• CAS No.: 237435-47-1
• Molecular Formula: C₁₃H₁₉N₃O₂
• Molecular Weight: 249.313
• Mol file: 237435-47-1.mol

Synonyms:cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide

Chemical Property of cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide

There total 1 articles about cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclohexanecarbonylamino-3-oxo-butyric acid ethyl ester (61151-95-9) + acetamidine hydrochloride (124-42-5) → cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide (237435-47-1)

Guidance literature:

acetamidine hydrochloride; With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h;

2-cyclohexanecarbonylamino-3-oxo-butyric acid ethyl ester; In ethanol; at 20 ℃; Further stages.;

DOI:10.1021/jm000269t

Reference yield:

cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide (237435-47-1) → 6-cyclohexyl-2-methylpyrrolo[3,2-d]pyrimidine-4-ol (237435-48-2)

Guidance literature:

With sodium ethanolate; at 360 ℃; for 0.333333h;

DOI:10.1021/jm000269t

Reference yield:

cyclohexanecarboxylic acid (4-hydroxy-2,6-dimethyl-pyrimidin-5-yl)-amide (237435-47-1) → 4-chloro-6-cyclohexyl-2-methylpyrrolo[3,2-d]pyrimidine (237435-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / 0.33 h / 360 °C

2: POCl₃; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating

With sodium ethanolate; N,N-diethylaniline; trichlorophosphate; In 1,2-dichloro-ethane; 1: Madelung cyclization;

DOI:10.1021/jm000269t

upstream raw materials:

2-cyclohexanecarbonylamino-3-oxo-butyric acid ethyl ester

acetamidine hydrochloride

Downstream raw materials:

6-cyclohexyl-2-methylpyrrolo[3,2-d]pyrimidine-4-ol

4-chloro-6-cyclohexyl-2-methylpyrrolo[3,2-d]pyrimidine