3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

Base Information

Chemical Name:3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester
CAS No.:863579-19-5
Molecular Formula:C₂₉H₃₅NO₄
Molecular Weight:461.601
Hs Code.:

Synonyms:3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

There total 4 articles about 3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 791814-38-5
2-[2-(tetrahydropyran-2-yloxy)ethoxy]phenylboronic acid

: 863579-19-5
3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 7h; Heating;
DOI:10.1021/jm0610245

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 863579-19-5
3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / p-toluenesulfonic acid monohydrate / CHCl₃ / 1 h / 20 °C

2.1: triisopropyl borate; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 56 percent / aq. HCl / tetrahydrofuran; hexane

3.1: 77 percent / NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 7 h / Heating

With n-butyllithium; Triisopropyl borate; sodium hydrogencarbonate; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; chloroform; water; 3.1: Suzuki coupling;
DOI:10.1021/jm0610245

Reference yield:

: 1074-16-4
2-bromophenylethyl alcohol

: 863579-19-5
3-cyclohexyl-2-{2-[2-(tetrahydropyran-2-yloxy)ethyl]phenyl}-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / p-toluenesulfonic acid monohydrate / CHCl₃ / 1 h / 20 °C

2.1: triisopropyl borate; n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 56 percent / aq. HCl / tetrahydrofuran; hexane

3.1: 77 percent / NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 7 h / Heating

With n-butyllithium; Triisopropyl borate; sodium hydrogencarbonate; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; chloroform; water; 3.1: Suzuki coupling;
DOI:10.1021/jm0610245