(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

Base Information

Chemical Name:(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran
CAS No.:323192-79-6
Molecular Formula:C₁₉H₁₉NO₅
Molecular Weight:341.364
Hs Code.:

Synonyms:(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

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Chemical Property of (S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

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Technology Process of (S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

There total 4 articles about (S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 323192-78-5
(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

: 323192-79-6
(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1021/jo0013711

Reference yield: 46.0%

: 323192-77-4
(2R,4R)-2-phenyl-4-(2-bromoethyl)-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 323192-79-6
(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

: 323192-78-5
(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1021/jo0013711

Reference yield:

: 323192-76-3
(2S,4R)-2-phenyl-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 323192-79-6
(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 88 percent / 0.75 h / -78 °C

2.1: 54 percent / LiOH / tetrahydrofuran; H₂O / 20 °C

With lithium hydroxide; sodium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1021/jo0013711