(S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

Base Information

Chemical Name:(S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester
CAS No.:323192-80-9
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:

Synonyms:(S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

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Chemical Property of (S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

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Technology Process of (S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

There total 4 articles about (S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 323192-79-6
(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

: 323192-80-9
(S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

Guidance literature:: Multistep reaction.;
DOI:10.1021/jo0013711

Reference yield:

: 323192-76-3
(2S,4R)-2-phenyl-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 323192-80-9
(S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 88 percent / 0.75 h / -78 °C

2.1: 54 percent / LiOH / tetrahydrofuran; H₂O / 20 °C

3.1: 80 percent

With lithium hydroxide; sodium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1021/jo0013711

Reference yield:

: 323192-77-4
(2R,4R)-2-phenyl-4-(2-bromoethyl)-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 323192-80-9
(S)-α-vinyl-α-(methoxycarbonyl)amino-4-phenylmethoxybenzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / LiOH / tetrahydrofuran; H₂O / 20 °C

2: 80 percent

With lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/jo0013711