(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

Base Information

Chemical Name:(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid
CAS No.:323192-78-5
Molecular Formula:C₁₉H₂₁NO₆
Molecular Weight:359.379
Hs Code.:

Synonyms:(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

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Chemical Property of (S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

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Technology Process of (S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

There total 2 articles about (S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 323192-77-4
(2R,4R)-2-phenyl-4-(2-bromoethyl)-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 323192-79-6
(S)-2-oxo-3-(4-phenylmethoxy)phenyl-3-(methoxycarbonyl)aminotetrahydrofuran

: 323192-78-5
(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1021/jo0013711

Reference yield:

: 323192-76-3
(2S,4R)-2-phenyl-4-((4-phenylmethoxy)phenyl)-5-oxo-3-oxazolidinecarboxylic acid methyl ester

: 323192-78-5
(S)-α-(2-hydroxyethyl)-α-((methylcarboxy)amino)-4-(phenylmethoxy)benzeneacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 88 percent / 0.75 h / -78 °C

2.1: 46 percent / LiOH / tetrahydrofuran; H₂O / 20 °C

With lithium hydroxide; sodium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1021/jo0013711