(2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt

Base Information

• Chemical Name: (2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt
• CAS No.: 110544-98-4
• Molecular Formula: C₁₂H₂₃N*C₁₈H₂₅NO₆
• Molecular Weight: 532.721
• Mol file: 110544-98-4.mol

Synonyms:(2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt

Chemical Property of (2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Dicyclohexylamine(S)-6-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-6-oxohexanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt

There total 1 articles about (2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

benzyl bromide (100-39-0) + Nα-(tert-butoxycarbonyl)-L-α-aminoadipic acid (77302-72-8) + N-cyclohexyl-cyclohexanamine (101-83-7) → (2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt (110544-98-4)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 24h;

DOI:10.1021/jm00088a028

Reference yield: 98.0%

(2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt (110544-98-4) + bis (141043-95-0) → bis (141043-96-1)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 26h; Heating;

DOI:10.1021/jm00088a028

Reference yield: 84.0%

(2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoic acid dicyclohexylammonium salt (110544-98-4) + (S)-3-hydroxy-15-methylhexadecanamide (171272-35-8) → (3S)-3-{(2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoyl}oxy-15-methylhexadecanamide (171272-37-0)

Guidance literature:

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane;

DOI:10.7164/antibiotics.51.655

upstream raw materials:

benzyl bromide

N^α-(tert-butoxycarbonyl)-L-α-aminoadipic acid

N-cyclohexyl-cyclohexanamine

Downstream raw materials:

bis

d(-Cys(Trt)-D-Val-OBzl)-OBzlBoc-

(3S)-3-{(2S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)aminopentanoyl}oxy-15-methylhexadecanamide

(S)-2-Amino-hexanedioic acid 6-benzyl ester 1-((S)-1-carbamoylmethyl-13-methyl-tetradecyl) ester