N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Base Information

Chemical Name:N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine
CAS No.:1131736-56-5
Molecular Formula:C₁₉H₁₃ClF₂N₄O
Molecular Weight:386.788
Hs Code.:

Synonyms:N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

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Chemical Property of N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Chemical Property:

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Technology Process of N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

There total 8 articles about N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1131736-54-3
6,10-dichloropyrido[4,3-c]-1,6-naphthyridine

: 1131736-53-2
6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine

: 36556-56-6
2-chloro-4,6-difluoroaniline

: 1131736-58-7
10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

: 1131736-56-5
N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 85 ℃; for 0.666667h;

Reference yield:

: 1131736-53-2
6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine

: 36556-56-6
2-chloro-4,6-difluoroaniline

: 1131736-56-5
N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 85 ℃;
DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

: 91940-86-2
2-ethoxyisonicotinic acid

: 1131736-56-5
N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / dichloromethane

2: triethylamine / dichloromethane

3: sec.-butyllithium / tetrahydrofuran / -78 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 100 °C

5: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

6: trichlorophosphate / 100 °C / Microwave irradiation

7: sodium t-butanolate / tetrahydrofuran / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sec.-butyllithium; sodium hexamethyldisilazane; sodium carbonate; triethylamine; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2014.02.011