10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

Base Information

Chemical Name:10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine
CAS No.:1131736-58-7
Molecular Formula:C₁₇H₈Cl₂F₂N₄
Molecular Weight:377.18
Hs Code.:

Synonyms:10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

Suppliers and Price of 10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

There total 8 articles about 10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1131736-54-3
6,10-dichloropyrido[4,3-c]-1,6-naphthyridine

: 1131736-53-2
6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine

: 36556-56-6
2-chloro-4,6-difluoroaniline

: 1131736-58-7
10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

: 1131736-56-5
N-(2-chloro-4,6-difluorophenyl)-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 85 ℃; for 0.666667h;

Reference yield:

: C₁₁H₆ClN₃O

: 36556-56-6
2-chloro-4,6-difluoroaniline

: 1131736-58-7
10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

Guidance literature:: With sodium t-butanolate; In tetrahydrofuran; at 85 ℃;
DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

: 91940-86-2
2-ethoxyisonicotinic acid

: 1131736-58-7
10-chloro-N-(2-chloro-4,6-difluorophenyl)pyrido[4,3-c]-1,6-naphthyridin-6-amine

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / dichloromethane

2: triethylamine / dichloromethane

3: sec.-butyllithium / tetrahydrofuran / -78 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 100 °C

5: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

6: trichlorophosphate / 100 °C / Microwave irradiation

7: sodium t-butanolate / tetrahydrofuran / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sec.-butyllithium; sodium hexamethyldisilazane; sodium carbonate; triethylamine; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2014.02.011