(R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

Base Information

Chemical Name:(R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester
CAS No.:1383617-29-5
Molecular Formula:C₂₁H₂₇ClNO₆PS
Molecular Weight:487.941
Hs Code.:

Synonyms:(R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

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Chemical Property of (R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

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Technology Process of (R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

There total 12 articles about (R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383617-34-2
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

: 1383617-29-5
(R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

Guidance literature:: (R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane; With hydrogenchloride; In tetrahydrofuran; methanol; at 15 - 25 ℃; for 24h;

With trimethylsilyl iodide; In acetonitrile; for 2h; Inert atmosphere; Cooling with ice;

Reference yield:

: C₁₄H₁₇BrClNO₂

: 1383617-29-5
(R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 1 h / 15 - 25 °C

2.1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 17 h / Inert atmosphere; Reflux

4.1: triethylamine / water; acetonitrile / 60 h / 15 - 25 °C / Inert atmosphere

5.1: carbon tetrabromide; pyridine / pyridine / 4 h / Inert atmosphere; Cooling with ice

6.1: hydrogenchloride / methanol; tetrahydrofuran / 24 h / 15 - 25 °C

6.2: 2 h / Inert atmosphere; Cooling with ice

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; ethanol; carbon tetrabromide; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; water; acetonitrile;

Reference yield:

: 1260511-71-4
6-ethoxy-1,3-benzoxathiol-2-one

: 1383617-29-5
(R)-2-allyl-2-amino-4-{2-chloro-4-((5-ethoxy-2-hydroxy)phenylthio)phenyl}butylphosphoric acid monoester

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 17 h / Inert atmosphere; Reflux

3.1: triethylamine / water; acetonitrile / 60 h / 15 - 25 °C / Inert atmosphere

4.1: carbon tetrabromide; pyridine / pyridine / 4 h / Inert atmosphere; Cooling with ice

5.1: hydrogenchloride / methanol; tetrahydrofuran / 24 h / 15 - 25 °C

5.2: 2 h / Inert atmosphere; Cooling with ice

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbon tetrabromide; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; water; acetonitrile;