(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

Base Information

Chemical Name:(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane
CAS No.:1383617-34-2
Molecular Formula:C₃₃H₄₇ClNO₁₀PS
Molecular Weight:716.23
Hs Code.:

(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

Synonyms:(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

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Chemical Property of (R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

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Technology Process of (R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

There total 11 articles about (R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383617-33-1
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-((2-((tert-butoxy)carbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}butan-1-ol

: 121-45-9
phosphorous acid trimethyl ester

: 1383617-34-2
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

Guidance literature:: With pyridine; carbon tetrabromide; In pyridine; for 4h; Inert atmosphere; Cooling with ice;

Reference yield:

: 1260511-61-2
methyl (R)-2-allyl-4-(4-bromo-2-chlorophenyl)-2-(((tert-butoxy)carbonyl)amino)butyrate

: 1383617-34-2
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

2: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 17 h / Inert atmosphere; Reflux

3: triethylamine / water; acetonitrile / 60 h / 15 - 25 °C / Inert atmosphere

4: carbon tetrabromide; pyridine / pyridine / 4 h / Inert atmosphere; Cooling with ice

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium borohydride; ethanol; carbon tetrabromide; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; pyridine; water; acetonitrile;

Reference yield:

: 7735-56-0
5-hydroxybenzo[d][1,3]oxathiol-2-one

: 1383617-34-2
(R)-2-allyl-2-(((tert-butoxy)carbonyl)amino)-4-{2-chloro-4-(((2-tert-butoxycarbonyl)hydroxy)-5-ethoxyphenylthio)phenyl}-1-((dimethoxyphosphoryl)oxy)butane

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 15 - 25 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

3: N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 17 h / Inert atmosphere; Reflux

4: triethylamine / water; acetonitrile / 60 h / 15 - 25 °C / Inert atmosphere

5: carbon tetrabromide; pyridine / pyridine / 4 h / Inert atmosphere; Cooling with ice

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; pyridine; water; N,N-dimethyl-formamide; acetonitrile;