2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate

Base Information

• Chemical Name: 2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate
• CAS No.: 384344-20-1
• Molecular Formula: C₁₄H₁₅NO₅S
• Molecular Weight: 309.343
• Mol file: 384344-20-1.mol

Synonyms:2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate

Chemical Property of 2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate

There total 1 articles about 2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride (14187-25-8) + p-toluenesulfonyl chloride (98-59-9) → 2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate (384344-20-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 24h;

DOI:10.1016/S0040-4020(01)00871-7

Reference yield: 88.0%

2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate (384344-20-1) → 2,6-bis(chloromethyl)-3-hydroxypyridine p-toluenesulfonate (384344-22-3)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; Heating;

DOI:10.1016/S0040-4020(01)00871-7

Reference yield:

2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate (384344-20-1) → 2,6-bis[((3-chloromethylphenyl)thio)methyl]-3-hydroxypyridine p-toluenesulfonate

Guidance literature:

Multi-step reaction with 3 steps

1.1: 88 percent / Et₃N; MsCl / CH₂Cl₂ / Heating

2.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

2.2: 79 percent / 18-crown-6 / dimethylformamide / 24 h / 45 °C

3.1: 68 percent / Et₃N; MsCl / CH₂Cl₂ / Heating

With potassium carbonate; methanesulfonyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)00871-7

upstream raw materials:

3-hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride

p-toluenesulfonyl chloride

Downstream raw materials:

2,6-bis(chloromethyl)-3-hydroxypyridine p-toluenesulfonate

2,6-bis[((3-hydroxymethylphenyl)thio)methyl]-3-hydroxypyridine p-toluenesulfonate

toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester