methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

Base Information

Chemical Name:methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate
CAS No.:878158-11-3
Molecular Formula:C₃₅H₃₃NO₄
Molecular Weight:531.651
Hs Code.:

Synonyms:methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

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Chemical Property of methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

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Technology Process of methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

There total 9 articles about methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 878158-10-2
(E)-1-(3-(2-aminoethyl)phenyl)-2-(O-methyl hydrocinnam-3’-yl)-ethene

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 878158-11-3
methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 24h;
DOI:10.1039/c4ob01926a

Reference yield:

: 3650-77-9
methyl 3-(3'-bromophenyl)-acrylate

: 878158-11-3
methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; nickel(II) acetate tetrahydrate; hydrogen / ethyl acetate; methanol / 20 °C / 750.08 Torr

2: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 20 °C

4: sodium carbonate / 1,4-dioxane; water / 24 h / 20 °C

With sodium tetrahydroborate; hydrogen; palladium diacetate; nickel(II) acetate tetrahydrate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c4ob01926a

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 878158-11-3
methyl trans-3-{3-[2-[3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]vinyl]phenyl}propionate

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine; hydrogenchloride; pyridine / water / 105 °C

2: hydrogenchloride / water / 0.83 h / 130 °C / Microwave irradiation

3: sodium tetrahydroborate; nickel(II) acetate tetrahydrate; hydrogen / ethyl acetate; methanol / 20 °C / 750.08 Torr

4: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

5: trifluoroacetic acid / dichloromethane / 20 °C

6: sodium carbonate / 1,4-dioxane; water / 24 h / 20 °C

With piperidine; pyridine; hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium diacetate; nickel(II) acetate tetrahydrate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c4ob01926a