(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

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Chemical Name:(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid
CAS No.:121402-03-7
Molecular Formula:C₃₁H₅₀O₅Si
Molecular Weight:530.82
Hs Code.:

Synonyms:(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

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Chemical Property of (E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

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Technology Process of (E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

There total 10 articles about (E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 121402-02-6,121402-08-2
(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(E)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid benzyl ester

: 121402-03-7
(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 8h; Ambient temperature;
DOI:10.1016/S0040-4039(00)87892-2

Reference yield:

: 121401-98-7,121402-06-0
(E)-(S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-6,6-bis-ethylsulfanyl-hex-2-enoic acid ethyl ester

: 121402-03-7
(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C

2: 76 percent / ammonium formate / Pd/C / methanol / 8 h / Ambient temperature

With ammonium formate; lithium diisopropyl amide; palladium on activated charcoal; In methanol;
DOI:10.1016/S0040-4039(00)87892-2

Reference yield:

: 121401-97-6
(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-5,5-bis-ethylsulfanyl-pentan-2-one

: 121402-03-7
(E)-2-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(5-oxo-2,5-dihydro-furan-3-yl)-prop-(Z)-ylidene]-6-methyl-8-(trimethyl-cyclohex-1-enyl)-oct-5-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dimethoxy-ethane / 60 h / -20 °C

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C

3: 76 percent / ammonium formate / Pd/C / methanol / 8 h / Ambient temperature

With ammonium formate; lithium diisopropyl amide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(00)87892-2