5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

Base Information

Chemical Name:5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester
CAS No.:127472-36-0
Molecular Formula:C₁₈H₂₆ClNO₄
Molecular Weight:355.862
Hs Code.:

Synonyms:5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

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Chemical Property of 5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

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Technology Process of 5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

There total 3 articles about 5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 150942-98-6
t-butyl lithioacetate

: 127472-35-9
N-(4-chloro-2-formylphenyl)-2,2-dimethylpropionamide

: 127472-36-0
5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

Guidance literature:: In diethyl ether; at -78 ℃;
DOI:10.1021/jo00302a049

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 127472-36-0
5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyamide / diethyl ether; hexane / 0.33 h / -78 °C

2: 94 percent / diethyl ether / -78 °C

With lithium diisopropyl amide; In diethyl ether; hexane;
DOI:10.1021/jo00302a049

Reference yield:

: 65854-91-3
N-(4-chlorophenyl)-2,2-dimethylpropionamide

: 127472-36-0
5-Chloro-2-<(2,2-dimethyl-1-oxopropyl)amino>-β-hydroxybenzenepropanoic Acid, 1,1-Dimethylethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-butyllithium / 1) THF, 0 deg C, 2 h; 2) THF, 0 deg C, 1 h

2: 94 percent / diethyl ether / -78 °C

With n-butyllithium; In diethyl ether;
DOI:10.1021/jo00302a049