ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Base Information

Chemical Name:ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate
CAS No.:1344997-36-9
Molecular Formula:C₂₉H₃₆ClN₃O₃S
Molecular Weight:542.142
Hs Code.:

Synonyms:ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

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Chemical Property of ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

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Technology Process of ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

There total 5 articles about ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1344997-35-8
[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]acetaldehyde

: 1344997-36-9
ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Guidance literature:: 4-carbethoxypiperidine; [3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]acetaldehyde; With sodium acetate; acetic acid; In ethanol; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1344997-36-9
ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 3 h / 75 °C

1.2: Cooling with ice

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

4.1: hydrogenchloride; water / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

5.1: sodium acetate; acetic acid / ethanol / 0.17 h / 20 °C

With hydrogenchloride; potassium phosphate; tert.-butylnitrite; water; sodium acetate; acetic acid; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 1258440-61-7
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-amine

: 1344997-36-9
ethyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-4-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 20 °C

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

4: sodium acetate; acetic acid / ethanol / 0.17 h / 20 °C

With hydrogenchloride; potassium phosphate; tert.-butylnitrite; water; sodium acetate; acetic acid; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki Coupling;