cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

Base Information

Chemical Name:cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine
CAS No.:1202007-15-5
Molecular Formula:C₃₁H₃₁ClN₂O₂
Molecular Weight:499.052
Hs Code.:

Synonyms:cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

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Chemical Property of cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

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Technology Process of cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

There total 7 articles about cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923022-55-3
1-benzyloxy-7-chloro-6-fluoro-isoquinoline

: 1202006-68-5
cis-4-(1-aminocyclopropyl)-4-phenylcyclohexanol hydrochloride

: 1202007-15-5
cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

Guidance literature:: cis-4-(1-aminocyclopropyl)-4-phenylcyclohexanol hydrochloride; With sodium hydride; In ISOPROPYLAMIDE; mineral oil; at 0 - 20 ℃;

1-benzyloxy-7-chloro-6-fluoro-isoquinoline; In ISOPROPYLAMIDE; mineral oil;

Reference yield:

: 100-39-0
benzyl bromide

: 1202007-15-5
cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

Guidance literature:: Multi-step reaction with 2 steps

1: silver carbonate / tetrahydrofuran / 20 - 70 °C

2: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0 - 20 °C

With sodium hydride; silver carbonate; In tetrahydrofuran; ISOPROPYLAMIDE; mineral oil;

Reference yield:

: 923022-53-1
7-chloro-6-fluoro-2H-isoquinolin-1-one

: 1202007-15-5
cis-1-[4-(1-benzyloxy-7-chloro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-cyclopropylamine

Guidance literature:: Multi-step reaction with 2 steps

1: silver carbonate / tetrahydrofuran / 20 - 70 °C

2: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0 - 20 °C

With sodium hydride; silver carbonate; In tetrahydrofuran; ISOPROPYLAMIDE; mineral oil;