1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

Base Information

Chemical Name:1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one
CAS No.:74280-95-8
Molecular Formula:C₂₁H₂₃Cl₃N₂O₇S
Molecular Weight:553.848
Hs Code.:

Synonyms:1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

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Chemical Property of 1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

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Technology Process of 1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

There total 4 articles about 1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 73884-79-4
<<(Trichloroethoxy)carbonyl>oxy>acetyl Chloride

: 74280-93-6
1,2-secopenicillin tosylate

: 74280-95-8
1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; 1) -40 deg C, 30 min, 2) up to 0 deg C, 30 min.;
DOI:10.1021/jo01306a028

Reference yield:

: benzyl 2-[2-oxo-3β-(2-hydroxyacetamido)-4β-(methylthio)azetidin-1-yl]-3-methyl-2-butenoate

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 74280-95-8
1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

Guidance literature:: With pyridine; hydrogenchloride; sodium chloride; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 74231-21-3
<<(Trichloroethoxy)carbonyl>oxy>acetic acid

: 74280-95-8
1-<1-((Benzyloxy)carbonyl)-2-methylprop-1-enyl>-4β-(methylthio)-3β-<<<(trichloroethoxy)carbonyl>oxy>acetamido>azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / SOCl₂ / benzene / 2 h / Heating

2: 97 percent / Et₃N / CH₂Cl₂ / 1) -40 deg C, 30 min, 2) up to 0 deg C, 30 min.

With thionyl chloride; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jo01306a028